| | Day | Time | | Opponent | Score | | Record |
| November |
| | 1 | 6:00PM | vs. | Shawnee CC | W-92-72 | | 1-0 |
| | | 6:00PM | vs. | Rend Lake | W-69-61 | | 2-0 |
| | | 6:30PM | vs. | Wabash Valley | W-64-48 | | 3-0 |
| | 2 | 5:30PM | vs. | Parkland College | L-80-93 | | 3-1 |
| | | 7:00PM | vs. | Jefferson College | L-77-89 | | 3-2 |
| | 3 | 5:00PM | vs. | SWIC | L-58-61 | | 3-3 |
| | 5 | 12:30PM | vs. | SIC | L-61-73 | | 3-4 |
| | | 4:00PM | vs. | Kaskaskia | W-89-70 | | 4-4 |
| | | 5:30PM | vs. | Lake Land | L-59-66 | | 4-5 |
| | 6 | 12:00PM | vs. | Lake Land | L-65-70 | | 4-6 |
| | | 4:00PM | vs. | Olney Central | W-101-58 | | 5-6 |
| | | 4:00PM | vs. | Kaskaskia | W-72-58 | | 6-6 |
| | | 4:30PM | vs. | SIC | W-78-49 | | 7-6 |
| | | 5:00PM | vs. | Lincoln Trail | W-80-51 | | 8-6 |
| | Jefferson College Classic |
| | | 6:00PM | vs. | Rend Lake | L-47-62 | | 8-7 |
| | | 7:00PM | vs. | Wabash Valley | W-74-68 | | 9-7 |
| | Jefferson Classic |
| | | 8:00PM | vs. | College of Lake County | W-94-52 | | 10-7 |
| | 7 | | vs. | Wabash Valley | L-48-58 | | 10-8 |
| | Jefferson Classic |
| | | 2:00PM | vs. | Lincoln Trail | W-82-78 | | 11-8 |
| | Jefferson College Classic |
| | 8 | 5:30PM | vs. | Olney Central | W-69-63 | | 12-8 |
| | | 5:30PM | vs. | Three Rivers CC | W-69-61 | | 13-8 |
| | 9 | 6:00PM | vs. | Illinois Central College | L-57-63 | | 13-9 |
| | 10 | 5:30PM | vs. | Vincennes University | W-71-64 | | 14-9 |
| | 12 | 5:00PM | vs. | Rend Lake | L-68-69 | | 14-10 |
| | | 6:00PM | vs. | Danville Area CC | W-72-42 | | 15-10 |
| | | 6:00PM | vs. | Lincoln Trail | W-99-66 | | 16-10 |
| | Cincinnati State Classic |
| | | 6:00PM | vs. | Kaskaskia | W-80-65 | | 17-10 |
| | 13 | 12:00PM | vs. | Lincoln Trail | W-87-49 | | 18-10 |
| | Cincinnati State Classic |
| | | 3:00PM | vs. | Rend Lake | L-68-80 | | 18-11 |
| | | 4:30PM | vs. | Vincennes University | L-66-73 | | 18-12 |
| | 15 | 5:30PM | vs. | Logan Chiropractic | W-64-53 | | 19-12 |
| | 16 | 4:00PM | vs. | Lincoln Trail | W-88-62 | | 20-12 |
| | | 6:00PM | vs. | Oakland City University | W-72-67 | | 21-12 |
| | | 7:00PM | vs. | Mineral Area College | W-81-62 | | 22-12 |
| | 17 | 5:30PM | vs. | Wabash Valley | L-41-69 | | 22-13 |
| | | 6:00PM | vs. | Illinois Central College | W-75-55 | | 23-13 |
| | 19 | 5:30PM | vs. | Lake Land | L-57-77 | | 23-14 |
| | | 7:00PM | vs. | Lincoln Land CC | W-75-66 | | 24-14 |
| | 20 | 1:00PM | vs. | SIC | L-47-66 | | 24-15 |
| | | 1:00PM | vs. | Cincinnati State Technical and CC | L-69-89 | | 24-16 |
| | | 2:00PM | vs. | Southern Illinois-Edwardsville | W-95-79 | | 25-16 |
| | SIUE Club Team |
| | | 3:00PM | vs. | Danville Area CC | W-91-45 | | 26-16 |
| | | 5:00PM | vs. | Kaskaskia | L-53-56 | | 26-17 |
| | | 5:30PM | vs. | Lewis & Clark CC | L-64-66 | | 26-18 |
| | 21 | 12:00PM | vs. | Cincinnati State Technical and CC | W-99-77 | | 27-18 |
| | 22 | 7:00PM | vs. | Blackburn College | W-77-48 | | 28-18 |
| | 23 | 5:30PM | vs. | Olney Central | W-85-46 | | 29-18 |
| | | 5:30PM | vs. | McKendree University | W-76-63 | | 30-18 |
| | 24 | 6:00PM | vs. | Kaskaskia | W-92-64 | | 31-18 |
| | 27 | 5:30PM | vs. | Danville Area CC | W-67-56 | | 32-18 |
| | 29 | 6:00PM | vs. | Three Rivers CC | W-81-61 | | 33-18 |
| | | 7:00PM | vs. | McKendree University | W-50-40 | | 34-18 |
| | 30 | 5:30PM | vs. | Lake Land | L-61-65 | | 34-19 |
| | | 5:30PM | vs. | State Fair CC | L-71-76 | | 34-20 |
| December |
| | 1 | 5:30PM | vs. | Lincoln Trail | L-75-86 | | 34-21 |
| | | 6:00PM | vs. | Parkland College | L-55-78 | | 34-22 |
| | 2 | 4:00PM | vs. | SWIC | L-54-65 | | 34-23 |
| | Vincennes Sodexho Classic |
| | | 6:00PM | vs. | Olney Central | W-67-66 | | 35-23 |
| | Vincennes Sodexho Classic |
| | 3 | 12:30PM | vs. | SIC | L-54-81 | | 35-24 |
| | Iowa Western Classic |
| | | 4:00PM | vs. | Wabash Valley | L-72-76 | | 35-25 |
| | Moberly Classic |
| | | 4:00PM | vs. | Southern Illinois-Edwardsville | W-80-62 | | 36-25 |
| | | 5:00PM | vs. | Olney Central | W-121-78 | | 37-25 |
| | Vincennes Sodexho Classic |
| | | 6:00PM | vs. | SWIC | W-75-64 (OT) | | 38-25 |
| | Vincennes Sodexho Classic |
| | | 6:00PM | vs. | Lincoln Trail | W-91-48 | | 39-25 |
| | Three Rivers Classic |
| | | 8:00PM | vs. | Rend Lake | W-66-60 | | 40-25 |
| | 4 | 11:00AM | vs. | Olney Central | W-85-71 | | 41-25 |
| | Vincennes Sodexho Classic |
| | | 12:00PM | vs. | Parkland College | L-66-76 | | 41-26 |
| | | 1:30PM | vs. | Wabash Valley | L-59-85 | | 41-27 |
| | Moberly Classic |
| | | 2:00PM | vs. | SWIC | L-59-62 | | 41-28 |
| | Vincennes Sodexho Classic |
| | | 2:00PM | vs. | Rend Lake | W-101-42 | | 42-28 |
| | | 4:00PM | vs. | Lincoln Trail | W-94-52 | | 43-28 |
| | Three Rivers Classic |
| | | 4:00PM | vs. | SIC | W-59-56 | | 44-28 |
| | 6 | 5:30PM | vs. | Millikin University | W-73-48 | | 45-28 |
| | | 5:30PM | vs. | Kaskaskia | W-64-60 | | 46-28 |
| | 7 | 5:30PM | vs. | Vincennes University | L-66-108 | | 46-29 |
| | 8 | 5:30PM | vs. | Danville Area CC | W-97-40 | | 47-29 |
| | 10 | 4:00PM | vs. | Wabash Valley | L-73-74 | | 47-30 |
| | Gulf Coast CC @ Vincennes Classic |
| | 11 | 12:00PM | vs. | Wabash Valley | L-47-79 | | 47-31 |
| | Vincennes Classic - Lindsey Wilson JV |
| | | 12:00PM | vs. | Kaskaskia | W-60-40 | | 48-31 |
| | | 2:00PM | vs. | Olney Central | L-36-53 | | 48-32 |
| | Lincoln Trail Shootout |
| | | 2:00PM | vs. | Lake Land | L-58-64 | | 48-33 |
| | | 3:30PM | vs. | SIC | W-69-56 | | 49-33 |
| | | 4:00PM | vs. | Black Hawk College-East | L-56-77 | | 49-34 |
| | | 5:00PM | vs. | Logan | W-72-64 | | 50-34 |
| | 12 | 12:00PM | vs. | Kaskaskia | W-69-65 | | 51-34 |
| | | 2:00PM | vs. | Olney Central | L-53-75 | | 51-35 |
| | Lincoln Trail Shootout |
| | 14 | 5:30PM | vs. | Three Rivers CC | W-107-73 | | 52-35 |
| | 15 | 5:30PM | vs. | Lincoln Trail | W-73-56 | | 53-35 |
| | | 7:00PM | vs. | Mineral Area College | L-34-54 | | 53-36 |
| | 18 | 1:00PM | vs. | Fort Scott CC | L-36-44 (OT) | | 53-37 |
| | | 2:00PM | vs. | Lincoln Trail | W-75-52 | | 54-37 |
| | 19 | 1:00PM | vs. | State Fair CC | L-58-70 | | 54-38 |
| | 21 | 6:00PM | vs. | Kaskaskia | W-72-66 | | 55-38 |
| | 22 | 4:30PM | vs. | SIC | L-78-80 | | 55-39 |
| | 28 | 3:15PM | vs. | Lake Land | L-69-76 | | 55-40 |
| | 29 | 5:30PM | vs. | Lake Land | W-67-46 | | 56-40 |
| | 30 | 5:30PM | vs. | Lake Land | W-68-61 | | 57-40 |
| January |
| | 5 | 6:00PM | vs. | St. Mary-of-the-Woods College | W-89-60 | | 58-40 |
| * | 8 | 1:00PM | vs. | Rend Lake | W-85-66 | | 59-40 1-0 |
| * | | 4:30PM | vs. | Kaskaskia | W-74-46 | | 60-40 2-0 |
| * | | 5:30PM | vs. | SWIC | W-59-45 | | 61-40 3-0 |
| * | | 5:30PM | vs. | Wabash Valley | L-40-75 | | 61-41 3-1 |
| * | 10 | 4:30PM | vs. | SIC | W-73-63 | | 62-41 4-1 |
| * | | 5:30PM | vs. | Lake Land | L-67-86 | | 62-42 4-2 |
| * | | 5:30PM | vs. | SWIC | L-49-70 | | 62-43 4-3 |
| * | | 5:30PM | vs. | Logan | L-58-71 | | 62-44 4-4 |
| * | 12 | 5:30PM | vs. | Logan | L-80-85 | | 62-45 4-5 |
| * | | 5:30PM | vs. | SWIC | L-42-69 | | 62-46 4-6 |
| * | | 5:30PM | vs. | Lake Land | W-96-75 | | 63-46 5-6 |
| * | | 5:30PM | vs. | Lincoln Trail | W-66-61 | | 64-46 6-6 |
| * | 15 | 1:00PM | vs. | SIC | L-34-81 | | 64-47 6-7 |
| * | | 1:00PM | vs. | Wabash Valley | L-56-73 | | 64-48 6-8 |
| * | | 5:30PM | vs. | Olney Central | W-79-64 | | 65-48 7-8 |
| * | | 5:30PM | vs. | Kaskaskia | W-59-54 | | 66-48 8-8 |
| * | 17 | 4:30PM | vs. | Lincoln Trail | W-88-38 | | 67-48 9-8 |
| * | | 5:30PM | vs. | Olney Central | L-57-60 (OT) | | 67-49 9-9 |
| * | | 5:30PM | vs. | Rend Lake | W-79-56 | | 68-49 10-9 |
| * | | 5:30PM | vs. | Kaskaskia | W-56-50 | | 69-49 11-9 |
| * | 19 | 5:30PM | vs. | Olney Central | L-56-69 | | 69-50 11-10 |
| * | | 5:30PM | vs. | SWIC | W-65-50 | | 70-50 12-10 |
| * | | 5:30PM | vs. | Lincoln Trail | L-69-76 | | 70-51 12-11 |
| * | 22 | 1:00PM | vs. | Wabash Valley | L-50-76 | | 70-52 12-12 |
| * | | 4:30PM | vs. | Rend Lake | W-79-70 | | 71-52 13-12 |
| * | | 5:30PM | vs. | Lincoln Trail | W-101-76 | | 72-52 14-12 |
| * | | 5:30PM | vs. | Logan | W-95-80 | | 73-52 15-12 |
| | 24 | 5:30PM | vs. | Washington University | L-58-69 | | 73-53 |
| | | 7:00PM | vs. | Lewis & Clark CC | W-59-49 | | 74-53 |
| * | 26 | 5:30PM | vs. | Wabash Valley | L-59-83 | | 74-54 15-13 |
| * | | 5:30PM | vs. | SWIC | L-49-64 | | 74-55 15-14 |
| * | | 5:30PM | vs. | Rend Lake | W-82-74 | | 75-55 16-14 |
| * | | 5:30PM | vs. | SIC | W-83-58 | | 76-55 17-14 |
| | | 5:30PM | vs. | McKendree University | W-85-81 | | 77-55 |
| * | 29 | 10:00AM | vs. | Olney Central | L-67-73 | | 77-56 17-15 |
| * | | 1:00PM | vs. | Logan | L-53-64 | | 77-57 17-16 |
| * | | 5:30PM | vs. | Lake Land | L-72-79 | | 77-58 17-17 |
| * | | 5:30PM | vs. | Kaskaskia | L-57-60 | | 77-59 17-18 |
| | 31 | 5:30PM | vs. | SWIC | PPD | | | |
| | | 6:00PM | vs. | Wabash Valley | W-79-58 | | 78-59 |
| February |
| | 1 | 6:00PM | vs. | McKendree University | PPD | | | |
| * | 2 | 5:30PM | vs. | Logan | L-51-85 | | 78-60 17-19 |
| * | 5 | 1:00PM | vs. | Rend Lake | W-78-52 | | 79-60 18-19 |
| * | | 1:00PM | vs. | Kaskaskia | W-97-84 | | 80-60 19-19 |
| * | | 4:30PM | vs. | Wabash Valley | W-58-50 | | 81-60 20-19 |
| * | | 5:30PM | vs. | Olney Central | W-88-44 | | 82-60 21-19 |
| | 7 | 5:30PM | vs. | Vincennes University | L-72-95 | | 82-61 |
| | | 5:30PM | vs. | SWIC | W-53-46 | | 83-61 |
| * | | 5:30PM | vs. | Lincoln Trail | W-90-60 | | 84-61 22-19 |
| * | | 5:30PM | vs. | Lake Land | L-69-73 | | 84-62 22-20 |
| | 9 | 4:30PM | vs. | SIC | PPD | | | |
| * | | 5:30PM | vs. | Olney Central | W-89-66 | | 85-62 23-20 |
| * | | 5:30PM | vs. | Kaskaskia | W-68-54 | | 86-62 24-20 |
| * | | 5:30PM | vs. | Wabash Valley | L-64-69 | | 86-63 24-21 |
| * | | 5:30PM | vs. | Rend Lake | W-75-70 | | 87-63 25-21 |
| * | 12 | 1:00PM | vs. | Logan | W-70-67 | | 88-63 26-21 |
| * | | 1:00PM | vs. | Lincoln Trail | W-74-70 | | 89-63 27-21 |
| * | | 4:30PM | vs. | SWIC | L-61-66 | | 89-64 27-22 |
| * | | 5:30PM | vs. | Rend Lake | W-81-77 | | 90-64 28-22 |
| * | 14 | 5:30PM | vs. | SWIC | W-74-71 (2OT) | | 91-64 29-22 |
| * | | 5:30PM | vs. | Wabash Valley | L-50-77 | | 91-65 29-23 |
| * | | 5:30PM | vs. | Lake Land | L-89-98 (OT) | | 91-66 29-24 |
| * | | 5:30PM | vs. | SIC | L-74-86 (OT) | | 91-67 29-25 |
| * | 16 | 4:30PM | vs. | SIC | W-75-64 | | 92-67 30-25 |
| * | | 5:30PM | vs. | Kaskaskia | L-74-82 | | 92-68 30-26 |
| * | | 5:30PM | vs. | Wabash Valley | L-52-62 | | 92-69 30-27 |
| * | | 5:30PM | vs. | Logan | L-77-83 | | 92-70 30-28 |
| | 17 | 7:30PM | vs. | Greenville College | W-76-50 | | 93-70 |
| * | 19 | 12:00PM | vs. | SIC | L-53-98 | | 93-71 30-29 |
| * | | 1:00PM | vs. | Lake Land | W-96-72 | | 94-71 31-29 |
| * | | 5:30PM | vs. | Olney Central | W-87-83 | | 95-71 32-29 |
| * | | 5:30PM | vs. | Kaskaskia | W-88-40 | | 96-71 33-29 |
| * | 21 | 5:30PM | vs. | Lake Land | L-52-59 | | 96-72 33-30 |
| * | | 5:30PM | vs. | SIC | L-69-96 | | 96-73 33-31 |
| * | 23 | 5:30PM | vs. | Olney Central | W-77-46 | | 97-73 34-31 |
| * | | 5:30PM | vs. | Lincoln Trail | W-82-58 | | 98-73 35-31 |
| * | | 5:30PM | vs. | Lake Land | L-55-73 | | 98-74 35-32 |
| * | | 5:30PM | vs. | Logan | W-85-78 | | 99-74 36-32 |
| * | 26 | 1:00PM | vs. | SIC | L-63-76 | | 99-75 36-33 |
| * | | 1:00PM | vs. | SWIC | W-59-56 | | 100-75 37-33 |
| * | | 1:00PM | vs. | Rend Lake | W-81-66 | | 101-75 38-33 |
| * | | 5:30PM | vs. | Lincoln Trail | W-90-66 | | 102-75 39-33 |
| March |
| | 1 | 7:00PM | vs. | Olney Central | W-78-49 | | 103-75 |
| | Quarterfinals of 2010-11 Region XXIV Tournament |
| | | 7:00PM | vs. | Rend Lake | W-83-45 | | 104-75 |
| | Region XXIV Tournament |
| | | 7:00PM | vs. | Lincoln Trail | W-111-63 | | 105-75 |
| | Quarterfinals of the Region XXIV Tournament |
| | | 7:00PM | vs. | Kaskaskia | L-86-88 | | 105-76 |
| | 4 | | vs. | Kaskaskia | W-68-50 | | 106-76 |
| | Region XXIV Tournament |
| | | 8:00PM | vs. | Wabash Valley | L-49-62 | | 106-77 |
| | Semi-Final of Region XXIV Tournament |
| | 5 | 7:00PM | vs. | Wabash Valley | W-57-53 | | 107-77 |
| | Region XXIV Championship |
